ParkinsonCanadaV1, Main, Exploration, bibRecord, 000744

Effects of subthalamic nucleus stimulation on motor cortex plasticity in Parkinson disease

Identifieur interne : 000744 ( Main/Exploration ); précédent : 000743; suivant : 000745

Effects of subthalamic nucleus stimulation on motor cortex plasticity in Parkinson disease

Auteurs : Sang Jin Kim ; Kaviraja Udupa ; Zhen Ni ; Elena Moro ; Carolyn Gunraj ; Filomena Mazzella ; Andres M. Lozano ; Mojgan Hodaie ; Anthony E. Lang ; Robert Chen

Source :

Neurology [ 0028-3878 ] ; 2015.

RBID : PMC:4534071

English descriptors

KwdEn :
- Aged, Deep Brain Stimulation (trends), Evoked Potentials, Motor (physiology), Female, Humans, Long-Term Potentiation (physiology), Male, Middle Aged, Motor Cortex (physiology), Neuronal Plasticity (physiology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Subthalamic Nucleus (physiology), Treatment Outcome.
MESH :
- physiology : Evoked Potentials, Motor, Long-Term Potentiation, Motor Cortex, Neuronal Plasticity, Subthalamic Nucleus.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- trends : Deep Brain Stimulation.
- Aged, Female, Humans, Male, Middle Aged, Treatment Outcome.

Abstract

Objective:

We hypothesized that subthalamic nucleus (STN) deep brain stimulation (DBS) will improve long-term potentiation (LTP)-like plasticity in motor cortex in Parkinson disease (PD).

Methods:

We studied 8 patients with PD treated with STN-DBS and 9 age-matched healthy controls. Patients with PD were studied in 4 sessions in medication (Med) OFF/stimulator (Stim) OFF, Med-OFF/Stim-ON, Med-ON/Stim-OFF, and Med-ON/Stim-ON states in random order. Motor evoked potential amplitude and cortical silent period duration were measured at baseline before paired associated stimulation (PAS) and at 3 different time intervals (T0, T30, T60) up to 60 minutes after PAS in the abductor pollicis brevis and abductor digiti minimi muscles.

Results:

Motor evoked potential size significantly increased after PAS in controls (+67.7% of baseline at T30) and in patients in the Med-ON/Stim-ON condition (+55.8% of baseline at T30), but not in patients in the Med-OFF/Stim-OFF (−0.4% of baseline at T30), Med-OFF/Stim-ON (+10.3% of baseline at T30), and Med-ON/Stim-OFF conditions (+17.3% of baseline at T30). Cortical silent period duration increased after PAS in controls but not in patients in all test conditions.

Conclusions:

Our findings suggest that STN-DBS together with dopaminergic medications restore LTP-like plasticity in motor cortex in PD. Restoration of cortical plasticity may be one of the mechanisms of how STN-DBS produces clinical benefit.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534071

DOI: 10.1212/WNL.0000000000001806
PubMed: 26156511
PubMed Central: 4534071

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><sec><title>Objective:</title>
<p>We hypothesized that subthalamic nucleus (STN) deep brain stimulation (DBS) will improve long-term potentiation (LTP)-like plasticity in motor cortex in Parkinson disease (PD).</p>
</sec>
<sec><title>Methods:</title>
<p>We studied 8 patients with PD treated with STN-DBS and 9 age-matched healthy controls. Patients with PD were studied in 4 sessions in medication (Med) OFF/stimulator (Stim) OFF, Med-OFF/Stim-ON, Med-ON/Stim-OFF, and Med-ON/Stim-ON states in random order. Motor evoked potential amplitude and cortical silent period duration were measured at baseline before paired associated stimulation (PAS) and at 3 different time intervals (T0, T30, T60) up to 60 minutes after PAS in the abductor pollicis brevis and abductor digiti minimi muscles.</p>
</sec>
<sec><title>Results:</title>
<p>Motor evoked potential size significantly increased after PAS in controls (+67.7% of baseline at T30) and in patients in the Med-ON/Stim-ON condition (+55.8% of baseline at T30), but not in patients in the Med-OFF/Stim-OFF (−0.4% of baseline at T30), Med-OFF/Stim-ON (+10.3% of baseline at T30), and Med-ON/Stim-OFF conditions (+17.3% of baseline at T30). Cortical silent period duration increased after PAS in controls but not in patients in all test conditions.</p>
</sec>
<sec><title>Conclusions:</title>
<p>Our findings suggest that STN-DBS together with dopaminergic medications restore LTP-like plasticity in motor cortex in PD. Restoration of cortical plasticity may be one of the mechanisms of how STN-DBS produces clinical benefit.</p>
</sec>
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La maladie de Parkinson au Canada (serveur d'exploration)

Effects of subthalamic nucleus stimulation on motor cortex plasticity in Parkinson disease

Effects of subthalamic nucleus stimulation on motor cortex plasticity in Parkinson disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
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